Degranulation cell technology: Some Elderly patients patients' eggs are very fragile . Apoptosis is very easy to occur in conventional degranulation cell operations. For such patients, the center has developed a rolling adhesion method to remove granular cells. This method avoids the damage caused by the mechanical force of conventional methods to the eggs , thereby significantly improving the survival rate of fragile eggs. This technology combined with the center's ICSI technology can significantly improve the egg utilization rate of patients.