Lianghui Diao
Lianghui Diao

Name:Lianghui Diao
Title:Doctor
Department:Clinical Research Center of Reproductive Medicine / Reproductive Immunity Center
Working years:
Technical specialty:Screening of endometrial receptive biomarkers, immunological regulation of the endometrial microenvironment, and clinical intervention strategies for repeated embryo implantation failures

Personal profile

1) K. Thiele, L. Diao, P.C. Arck, Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, Springer Berlin Heidelberg, 2017, pp. 1-18. (Review)

2) S. Liu, L. Diao, C. Huang, Y. Li, Y. Zeng, J.Y. Kwak-Kim, The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

3) Ding J L1, Diao L H1, Yin T L, Huang C Y, Yin B, Chen C, Zhang Y, Li J, Cheng Y X, and Zeng Y*. 2017. Aberrant expressions of endometrial Id3 and CTLA‐4 are associated with unexplained repeated implantation failure and recurrent miscarriage. American Journal of Reproductive Immunology 77: e12632. (co-first author)

4) Diao L H, Li G G, Zhu Y C, Tu W W, Huang C Y, Lian R C, Chen X, Li Y Y, Zhang T, and Huang Y. 2017. Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. American Journal of Reproductive Immunology 77: e12618.

5) Huang C1, Zhang H1, Chen X, Diao L, Lian R, Zhang X, Hu L, and Zeng Y*. 2016. Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case‐controlled study. American Journal of Reproductive Immunology 76: 326-332.

6) Chen X1, Yin B1, Lian R C, Zhang T, Zhang H Z, Diao L H, Li Y Y, Huang C Y, Liang D S, and Zeng Y. 2016. Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. American Journal of Reproductive Immunology 76: 432-438.

7) Wang X-D1, Gong Y1, Chen Z-L1, Gong B-N1, Xie J-J, Zhong C-Q, Wang Q-L, Diao L-H, Xu A, Han J and Li Y*(2015) TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation. Nature immunology 16, 1195–1203 (2015)

8) Liang P-Y, Diao L-H, Huang C-Y, Lian R-C, Chen X, Li G-G, Zhao J, Li Y-Y, He X-b, Zeng Y* (2015) The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure. Reproductive biomedicine online 31(6):823-6.

9) Huang C, Liang P, Diao L, Liu C, Chen X, Li G, Chen C, Zeng Y* (2015) Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. International journal of environmental research and public health 12: 10352-10361

10) Wan C-Y1, Song C1, Diao L-H, Li G-G, Bao Z-J, Hu X-D, Zhang H-Z, Zeng Y* (2014) Laser-assisted hatching improves clinical outcomes of vitrified–warmed blastocysts developed from low-grade cleavage-stage embryos: a prospective randomized study. Reproductive biomedicine online 28: 582-589

11) Xie J-J1, Liang J-Q1, Diao L-H, Altman A, Li Y* (2013) TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. The Journal of Immunology 190: 4027-4036

12) Wang K1, Diao L-H1, Gong Y, Liu X, Li Y* (2012) NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cellular signalling 24: 1556-1564 (co-first author)

He is the director of Clinical Research Center of Reproductive Medicine and head of Reproductive Immunity Center of Shenzhen Zhongshan Urology Hospital. He received his Ph.D. in Biochemistry and Molecular Biology from School of Life Sciences, Sun Yat-sen University in 2012. After graduation, he joined the Reproductive Medicine Center of Shenzhen Zhongshan Urology Hospital to conduct reproductive immunology research. During 2017-2018, he received postdoctoral training at the Maternal and Fetal Medical Center of the Ebende Hospital of the University of Hamburg in Germany. The research content is the mechanism of the immune cell metabolic signaling pathways in establishing the immune tolerance microenvironment in early pregnancy.The co-supervisor is Professor Petra Arck.

research direction:

His Research directions include screening of endometrial receptive biomarkers, immunological regulation of the endometrial microenvironment, and clinical intervention strategies for repeated embryo implantation failures.

Academic Achievements:

As of July 2018, he presided over 1 National Natural Science Youth Fund (2018-2020), 1 Special Fund for Science and Technology Development in Guangdong Province (2017-2019), and concluded 1 (2015-2017)Research Fund (CREATE) of the Merck Serono China Reproductive Medicine, 1 basic research project of Shenzhen Science and Technology Innovation Commission (2014-2016), and 1 clinical research project of Shenzhen Health and Family Planning Commission (2016-2018).he were magazine reviewers(such as Seminars in Immunopathology, American Journal of Reproductive Immunology, and Journal of Reproductive Immunology). He has published more than ten SCI papers with the first author and co-author..he has been granted 1 invention patent and 3 invention patents under review.,and received 1 Shenzhen Municipal Science and Technology Progress Award as a participant (2015).

A list of representative papers is as follows:

1) K. Thiele, L. Diao, P.C. Arck, Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, Springer Berlin Heidelberg, 2017, pp. 1-18. (Review)

2) S. Liu, L. Diao, C. Huang, Y. Li, Y. Zeng, J.Y. Kwak-Kim, The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

3) Ding J L1, Diao L H1, Yin T L, Huang C Y, Yin B, Chen C, Zhang Y, Li J, Cheng Y X, and Zeng Y*. 2017. Aberrant expressions of endometrial Id3 and CTLA‐4 are associated with unexplained repeated implantation failure and recurrent miscarriage. American Journal of Reproductive Immunology 77: e12632. (co-first author)

4) Diao L H, Li G G, Zhu Y C, Tu W W, Huang C Y, Lian R C, Chen X, Li Y Y, Zhang T, and Huang Y. 2017. Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. American Journal of Reproductive Immunology 77: e12618.

5) Huang C1, Zhang H1, Chen X, Diao L, Lian R, Zhang X, Hu L, and Zeng Y*. 2016. Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case‐controlled study. American Journal of Reproductive Immunology 76: 326-332.

6) Chen X1, Yin B1, Lian R C, Zhang T, Zhang H Z, Diao L H, Li Y Y, Huang C Y, Liang D S, and Zeng Y. 2016. Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. American Journal of Reproductive Immunology 76: 432-438.

7) Wang X-D1, Gong Y1, Chen Z-L1, Gong B-N1, Xie J-J, Zhong C-Q, Wang Q-L, Diao L-H, Xu A, Han J and Li Y*(2015) TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation. Nature immunology 16, 1195–1203 (2015)

8) Liang P-Y, Diao L-H, Huang C-Y, Lian R-C, Chen X, Li G-G, Zhao J, Li Y-Y, He X-b, Zeng Y* (2015) The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure. Reproductive biomedicine online 31(6):823-6.

9) Huang C, Liang P, Diao L, Liu C, Chen X, Li G, Chen C, Zeng Y* (2015) Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. International journal of environmental research and public health 12: 10352-10361

10) Wan C-Y1, Song C1, Diao L-H, Li G-G, Bao Z-J, Hu X-D, Zhang H-Z, Zeng Y* (2014) Laser-assisted hatching improves clinical outcomes of vitrified–warmed blastocysts developed from low-grade cleavage-stage embryos: a prospective randomized study. Reproductive biomedicine online 28: 582-589

11) Xie J-J1, Liang J-Q1, Diao L-H, Altman A, Li Y* (2013) TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. The Journal of Immunology 190: 4027-4036

12) Wang K1, Diao L-H1, Gong Y, Liu X, Li Y* (2012) NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cellular signalling 24: 1556-1564 (co-first author)

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